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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Humanitarian Military Journal</journal-id><journal-title-group><journal-title xml:lang="en">Humanitarian Military Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Гуманитарный военный журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="electronic">3034-7246</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">689989</article-id><article-id pub-id-type="doi">10.17816/hmj689989</article-id><article-id pub-id-type="edn">BYBLVM</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Pharmaceuticals for performance adjustment during regular physical activity</article-title><trans-title-group xml:lang="ru"><trans-title>Фармакологические средства для коррекции работоспособности при систематических физических нагрузках</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="spin">9831-2927</contrib-id><name-alternatives><name xml:lang="en"><surname>Bolshova</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Большова</surname><given-names>Елена Валерьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>bolshovaev@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="spin">8974-7477</contrib-id><name-alternatives><name xml:lang="en"><surname>Shabanov</surname><given-names>Petr D.</given-names></name><name xml:lang="ru"><surname>Шабанов</surname><given-names>Петр Дмитриевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>pdshabanov@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Lesgaft National State University of Physical Education, Sports and Health</institution></aff><aff><institution xml:lang="ru">Национальный государственный университет физической культуры, спорта и здоровья им. П.Ф. Лесгафта</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Institute of Experimental Medicine</institution></aff><aff><institution xml:lang="ru">Институт экспериментальной медицины</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-11-10" publication-format="electronic"><day>10</day><month>11</month><year>2025</year></pub-date><volume>1</volume><issue>3</issue><issue-title xml:lang="en">Humanitarian Military Journal</issue-title><issue-title xml:lang="ru">Гуманитарный военный журнал</issue-title><fpage>215</fpage><lpage>222</lpage><history><date date-type="received" iso-8601-date="2025-08-30"><day>30</day><month>08</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-09-18"><day>18</day><month>09</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://manmiljournal.ru/hmj/article/view/689989">https://manmiljournal.ru/hmj/article/view/689989</self-uri><abstract xml:lang="en"><p>Reasonable pharmacological support for elite athletes is an important issue not yet addressed. Therefore, it is required to find advanced approaches and means to boost physical and functional performance during regular physical activity. It is well known that active sports change the functional performance associated with adaptation to physical and psycho-emotional stress and, consequently, the degree of stress on regulatory mechanisms. Thus, there is a need to develop new, more advanced medical and biological technologies to enhance sports training. Scholars distinguish five different classes of performance-enhancing agents, including nutritional, physiological, psychological, pharmacological, and biomechanical. To enhance training performance, both physiological methods and pharmaceuticals are used. However, it should be noted that the drugs can also have adverse effects, primarily on the central nervous system, metabolism, heart, liver, kidneys, blood, and the human hormonal system. Reasonable pharmacological support for elite athletes is important. The review presents contemporary data on the means used to correct the body’s adaptive mechanisms, replenish expended energy, and restore performance during regular physical stress.</p></abstract><trans-abstract xml:lang="ru"><p>Обоснованная фармакологическая поддержка спортсменов высокой квалификации остается важной нерешенной проблемой. Поэтому поиск современных подходов и средств, повышающих физическую работоспособность и функциональное состояние при систематических физических нагрузках, не теряет своей актуальности. Известно, что в результате активной спортивной деятельности происходят изменения функционального состояния организма, связанные с адаптацией к физическим и психоэмоциональным нагрузкам, а следовательно, со степенью напряжения регуляторных механизмов. Поэтому возникает необходимость в разработке новых, более совершенных медико-биологических технологий для оптимизации спортивно-тренировочного процесса. Ученые выделяют пять различных классов средств, повышающих работоспособность: пищевые, физиологические, психологические, фармакологические, биомеханические. Для усиления работоспособности в спортивно-тренировочном процессе используются не только физиологические методы воздействия, но и фармакологические препараты. Вместе с тем следует отметить, что применение лекарственных средств может оказывать и нежелательные побочные эффекты, прежде всего, на центральную нервную систему, обменные процессы, сердце, печень, почки, кровь, гормональную систему человека. Обоснованная фармакологическая поддержка спортсменов высокой квалификации остается важной проблемой. В обзоре представлены современные сведения о средствах, применяющихся для коррекции адаптационно-приспособительных механизмов организма, восполнения затраченных энергетических ресурсов и восстановления работоспособности при систематических физических нагрузках.</p></trans-abstract><kwd-group xml:lang="en"><kwd>performance during physical exertion</kwd><kwd>general strengthening drugs</kwd><kwd>neuroprotectors</kwd><kwd>adaptogens</kwd><kwd>actoprotectors</kwd><kwd>antihypoxic drugs</kwd><kwd>metabolic brain activators</kwd><kwd>peptide bioregulators</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>работоспособность при физических нагрузках</kwd><kwd>препараты комплексного общеукрепляющего действия</kwd><kwd>нейропротекторы</kwd><kwd>адаптогены</kwd><kwd>актопротекторы</kwd><kwd>антигипоксанты</kwd><kwd>метаболические активаторы мозга</kwd><kwd>пептидные биорегуляторы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Makarova GA, Achkasov EE, Loktev SA. 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